Sentence examples for systemically applied from inspiring English sources
Drug targeting systems are nanometre-sized carrier materials designed for improving the biodistribution of systemically applied (chemo therapeutics.
Drug targeting systems are nanometer-sized carrier materials designed for improving the biodistribution of systemically applied (chemo-) therapeutics.
However, one of the main drawbacks of systemically applied cytokines is their high toxicity.
The central trigeminal activity was inhibited by systemically applied CGRP antagonists but not when the substance was applied to the dura mater; also effects on activity markers in the trigeminal ganglion were lacking when olcegepant was systemically applied [16 18].
In other animals, intra-VTA heroin-induced place preferences were challenged with systemically applied alprazolam (0.125 mg/kg IP).
Although systemically applied nanoparticles are quickly taken up by phagocytic cells, mainly macrophages, the interactions between engineered nanoparticles and macrophages are still not well defined.
This hypothesis is supported by studies in mouse models using melanoma B16-F100) in mutants lacking CD73 [ 13– 16] or inhibitors of CD73 [ 17] or systemically applying anti-CD73 antibodies [ 17].
Yet, N-acetylcysteine did not diffuse systemically when applied to the middle ear.
Second, SS enhances sound evoked activity in ACx when given systemically or applied locally to the LA or ACx, whereas it depresses ACx responses when only applied to the cochlea (Sun et al., 2009; Chen et al., 2012).
Mice received a full-thickness skin defect dorsally and BM-MSCs were either injected systemically or applied to the wound in a polymer implant, which resulted in accelerated wound closure in the treated mice (in both cellular treatments) when compared to the vehicle controls [ 36].
A good exemplar of this approach is the study of Li and Ren [ 42], in which cardiac-specific overexpression of IGF-I led to a small but significant increase in mouse lifespan, even though the anti-apoptotic effects of this manipulation would likely have limited organismic survival if it were applied systemically or to other organ systems.
