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Conversely, systemic uptake, albeit not negligible [36, 37], is limited after nebulization.
Notably, the intraperitoneal administration was found to prevent systemic uptake of the nanoparticles, with negligible accumulations in the liver and spleen.
Orally administered devices could enable the systemic uptake of biologic therapeutics by engineering around the physiological barriers present in the gastrointestinal (GI) tract.
The potential for systemic uptake of tenofovir when delivered topically is assessed through permeability studies.
Therefore, taurine is an ideal measure for systemic uptake of topically applied NCT.
The higher plasma concentration of [U-C]oleate could be partly explained by lower systemic uptake.
Similar(33)
Additionally, HIF2α induces the expression of FPN, DMT1 and DCYTB in enterocytes to promote systemic iron uptake (Peyssonnaux et al., 2007; Torti and Torti, 2013).
In humans, mild cold exposure increases plasma levels of fibroblast growth factor-21 (FGF-21) (Lee et al., 2013), a hormone that promotes systemic glucose uptake and oxidation.
In humans, the bulk of systemic magnesium uptake occurs via the small intestine and is mediated by the action of the TRPM6 (and probably TRPM7) cation channels (reviewed in [1], [2]).
An insulin sensitivity index for systemic glucose uptake (ISI; in µmol kg−1 min−1 pM−1) was calculated as the mean infusion rate of glucose (in mol kg−1 minecessaryssary to maintain euglycemia during the last 40 min of the hyperinsulinemic euglycemic clamp divided by the steady state plasma insulin concentration.
The urine metabolites served as biomarkers for systemic deltamethrin uptake.
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