Sentence examples for systemic toxicology from inspiring English sources

As colesevelam is not appreciably absorbed (see previous section "The colesevelam molecule"), discussion of systemic toxicology related directly to the molecule itself or metabolites is not germane.

Recent data on bioaccumulation in wildlife and humans point to a need for in-depth analyses of systemic toxicology, in particular with respect to reproduction and ontogeny.

Since fluorescence is one of the key mechanisms that has been used to evaluate the skin penetration of NPs, understanding the technical limitations of evaluation techniques has important real-world implications in the application of results to assess risk and potential systemic toxicology.

In conclusion, this systems toxicology approach has potential for product testing according to "21st Century Toxicology".

Determining systemic dose in toxicology studies will increase the understanding of potential mode of action (MOA) reducing the use of animals by avoiding unnecessary additional MOA studies.

While further GLP/GMP grade safety/toxicology studies mandated for experimental systems such as that described here are currently on-going, to date, the AAV-2/9 barrier modulating system for systemic drug delivery of therapeutics appears safe, tolerable and represents a novel form of chronic preventative therapy.

A potentially more rewarding approach would be to adopt from nutrition's sister disciplines of pharmacology and toxicology the analysis of systemic metabolism of a component with the Absorption, Distribution, Metabolism, Excretion (ADME) model.

In vivo toxicology will thus help address whether systemic toxicity and neurotoxicity may occur after exposure to WC-Co.

A standard textbook in toxicology provides the following distinction between systemic and local effects: "Local effects refer to those that occur at the site of first contact between the biological system and the toxicant" (Klaassen 2008).

Approaches taken to demonstrate vaccine safety by assessing systemic and local toxicity, biodistribution and persistence, immunogenicity and immunotoxicity, reproductive toxicology, safety pharmacology and genotoxicity within the current regulatory framework are presented.

Under the current big data scenario, it is expected that modern toxicology research will be able to better estimate the systemic effects of compounds on whole organisms and to translate this into better informed regulation of toxicants for animals and humans.