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An "ideal" knee prosthesis would prevent release of any metal ions into the patient's blood and thus protect him/her from any local or systemic toxic effects, cancer risk or activation of the immune system possibly resulting in hypersensitivity against components of the prosthesis.
The latter route of administration could potentially enhance siRNA retention in the lungs and reduce systemic toxic effects.
Monsanto then hired the scientist who led the study as a consultant, and company memos began acknowledging the "systemic toxic effects" of Aroclors, the brand name for PCBs.
Formaldehyde is an indoor pollutant, and studies have indicated neurotoxic characteristics and systemic toxic effects of this compound upon chronic and high doses of exposure.
In a previous study, mice were pulmonary exposed to Ag ENPs and local (lung) and systemic toxic effects together with biodistribution to organs including heart, liver, spleen and kidney were investigated.
Specifically, the individual parts of the infusion sets (the drip chamber, tube, flashball and injection site) are composed of numerous chemical compounds that can reach the patients' systemic circulation and induce local and systemic toxic effects.
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One should distinguish between local toxicity, the irritant action at the site of injection, and systemic toxicity, the toxic effect on the whole system (usually because of the effect on one or more internal organs).
To optimally stimulate NK cells with cytokines without the need for systemic, often toxic, cytokine administration, many efforts have been made to genetically engineer the NK cells to produce a variety of cytokines themselves.
The biomonitoring methods using mussels, Daphnia, algae, or natural bacteria are able to detect the total, mostly systemic, acute toxic effects of compounds such as herbicides and heavy metals.
The banding of the pulmonary artery induces no systemic or toxic effects, and the fixed constriction of the banding ensures a constant afterload, also when pulmonary vasodilators are administered.
Practice bee-safe pest control: Avoid the use of systemic bee-toxic pesticides in your garden (see Appendix A in the report here) and use alternative approaches such as providing habitat to attract beneficial insects that prey on pest insects in your garden.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com