Sentence examples for systemic therapeutics from inspiring English sources
Transdermal drug delivery is an attractive alternative to conventional techniques for administration of systemic therapeutics.
Systemic therapeutics targeting the peroxisome proliferator-activated receptors have been found to be beneficial in the treatment of diabetic retinopathy.
With new systemic therapeutics available the survival time will increase and orthopaedic surgeons will see more breast cancer patients with bone metastases.
Furthermore, the ductal type adenocarcinomas of the pancreas or distal bile ducts show an extremely poor prognosis that has been attributed to their disseminating growth pattern, extreme tendency for perineural sheet invasion, and their inaccessibility for systemic therapeutics, potentially due to their extensive desmoplastic stromal reaction.
A recent report showed the potential for atelocollagen-mediated systemic antisense therapeutics in a mouse model of bone metastasis without any side effects.
While further GLP/GMP grade safety/toxicology studies mandated for experimental systems such as that described here are currently on-going, to date, the AAV-2/9 barrier modulating system for systemic drug delivery of therapeutics appears safe, tolerable and represents a novel form of chronic preventative therapy.
This review discusses nucleic acid-based therapeutics, systemic and intracellular barriers to efficient nucleic acid delivery, and nanocarriers responsive to extracellular and intracellular biological stimuli to overcome individual barriers.
Genetically modified bone marrow-derived mesenchymal stem cells (MSCs) have proven to be efficient cell carriers for local or systemic delivery of therapeutics as well as growth factors to augment tissue formation.
Because the effects of many cancer therapeutics are systemic, employing a systems-based approach would efficiently facilitate circulating biomarker discovery in ACIC.
Orally and parenterally administered methotrexate (MTX) have had adverse systemic complications in RA therapeutics.
This approach can be used to develop effective therapeutics for systemic and intestinal immune-mediated inflammatory diseases.
