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Local and systemic staging confirmed the patient to be a smoker with no other co-morbidities.
Local and systemic staging confirmed the patient to be smoker with no other co-morbidities.
Moreover, systemic and local therapies are likely synergistic, and thus improvements in systemic staging and treatment may increase the ability of local therapies to improve overall survival.
In the systemic staging with [18F]FDG PET/CT, the lymphoma manifestations within the orbital cavities showed strong uptake (standardized uptake value; SUVmax of 8.7, tumour-to-background ratio (TTB) 4.2) and no further lymphoma lesions were detectable.
Systemic staging using CT was negative.
Systemic staging, including lumbar puncture, was negative.
Similar(48)
At the systemic stage, anthrax is accompanied by damage to many organs and tissues.
Through quorum sensing during bacterial growth, this cluster is expected to be down-regulated and relayed by up-regulation of manA (xanB in X. albilineans)—a gene that is also involved in biofilm formation in the later systemic stage of infection [ 86].
Inclusion criteria were: Confirmed pathologic diagnosis of invasive BC; stage I III with no prior systemic therapy; stage IV patients with no previous systemic therapy or in confirmed progression after such treatment; written informed consent.
Patients treated with curative intent (stage IIIB and IIIC, n = 146) developed systemic disease (stage IV) in 79 cases (54%) with a median time to systemic progression (TSP) of 26 months.
In the systemic disease stages, patients usually present with pronounced constitutional symptoms (weakness, fever, weight loss).
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