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However, applying doxorubicin locally vs systemically could lead to fewer systemic side effects such as cardiomyopathy.
This prevents systemic side effects on the cardiovascular system that are associated with the free drug.
The levonorgestrel intrauterine device (IUD) has associated systemic side effects.
However, their long-term use is associated with various oropharyngeal and systemic side and adverse effects.
The possibility of direct nose-to-brain transport offers enhanced targeting and reduced systemic side effects.
However, there is also a growing concern regarding its systemic side effects.
The biggest concern of using steroid therapy is the systemic side effects at high dose.
These compounds are intended for dermatological use further limiting possible systemic side effects.
Systemic side effects are not to be expected.
It is plausible that with extended duration of diabetes, the systemic side effects increase.
Dysphagia and systemic side effects were not reported in all the 5 trials [51, 56 60].
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