Sentence examples for systemic repercussions from inspiring English sources

Among the factors impeding discovery of new drugs is a lack of understanding of the complex biological systems underlying diseases and systemic repercussions of drug candidate target interactions.

Neuritis and cutaneous inflammation are prominent symptoms of both types of reaction with systemic repercussions, as seen in the occurrence of malaise, fever, and inflammation in other tissues.

The development of obesity triggers a vicious cycle in which subjects become obese, and the systemic repercussions of their disease process make them intolerant to exercise; therefore, they become more sedentary, which promotes additional weight gain.

The absence of significant systemic repercussions is related not only to the low amount of citrate used but also to the rapid conversion of citrate into bicarbonate, which takes place in the liver and muscles and results in a higher post-dialysis bicarbonataemia [ 1, 6, 7].

It is associated with an abnormal inflammatory response of the lung to toxic particles and gases, especially tobacco, with important systemic repercussions [ 1] It is a very prevalent health problem worldwide and is a frequent cause of morbidity and mortality in developed countries.

Knowledge and skills are capable of determining the power rapports in every sphere of social, organizational and systemic life, with obvious repercussions on citizenship and democracy [76].

Although the functionalization of drug delivery vectors with cellular materials has been shown to provide synthetic particles with unique biological properties, these approaches may have undesirable immunological repercussions upon systemic administration.

The President is taking steps in the right direction, but the repercussions of systemic injustice in law enforcement began in the aftermath of social unrest in the 1960s.

In April of 1999, Kunstler wrote, "It seems to me that the Y2K problem is so broad, systemic, and unprecedented that imagining its repercussions calls for something besides conventional thinking".

This functional repercussion of LOX upregulation in systemic and adipose tissue metabolism has been suggested previously in a transgenic mouse model that specifically overexpresses HIF-1α in the adipose tissue (Halberg et al., 2009).

In Chagas disease, local immune response represented by the inflammatory infiltrate and systemic immune response are both responsible for the symptomatology and repercussions of the disease.