In my view, making the systemic risk rationale for guidances and reviews more explicit is certainly feasible and would be a useful step toward a more systemic orientation for financial regulation and supervision.
The existence of systemic banks provides a rationale for the central bank to act as lender of last resort for non-systemic banks in a larger range of their liquidity shortfalls.
This is the first demonstration of the use of biodegradable nanoparticles to deliver genome-editing agents to human primary cells, and provides a strong rationale for systemic delivery of complex nucleic acid mixtures designed for gene correction.
There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.
Neoadjuvant chemotherapy was introduced into treatment paradigms for curable head and neck cancer in the early 1970s in an effort to reduce the magnitude of mutilating surgery and to provide a rationale for adjuvant systemic chemotherapy in patients who responded to initial chemotherapy.
This is not the case: Bank regulators have long viewed the containment of systemic risk as a primary rationale for capital requirements.
Additionally, these two regimens are expected to result in systemic drug concentrations substantially lower than the minimum level to elicit systemic CFD inhibition and provide strong scientific rationale for the recommended phase III dosing regimens.
With evidence for disordered pain processing centrally and peripherally in fibromyalgia one can consider it a neuropathic condition providing a rationale for the use of systemic local anaesthetics.
In the present retrospective analysis the rationale for intraperitoneal irinotecan was response to systemic irinotecan-based chemotherapy in seven patients, disease progression under oxaliplatin-based systemic chemotherapy in three and oxaliplatin-associated peripheral polyneuropathy ≥ grade 3 in two patients.
On the other hand, these patients are also at high risk for distant metastases, which built the rationale for an additive use of systemic therapy.
