He predicted "a financial disaster of global-systemic proportions" in early 2008, long before most civilians, and his calls since then have been consistently, gloomily, accurate.
"The transmission of tensions among sovereigns, across banks and between the two intensified to take on systemic crisis proportions not witnessed since the collapse of Lehman Brothers three years ago," the report said.
In patients not receiving systemic treatment, the proportions of risk categories were 44% low, 16% intermediate, and 40% high CDK-based risk.
Interestingly, patients with hyperglycemia were less likely to present sign of systemic compromise: smaller proportions presented with a diastolic blood pressure <60 mm Hg, or CSF white blood cell counts <1000 cells/mm, and they had higher platelet counts.
In all countries except Denmark, broad-spectrum penicillins formed the largest subgroup of prescribed systemic antibiotics, with proportions varying between 23.8% in Germany and 57.4% in Italy (Table 2).
Since unfavorable primary tumor characteristics solely have become a sufficient indication for adjuvant systemic treatment, the proportion of patients with an indication for systemic treatment has increased substantially.
The answer, as far as I can see, is a systemic rigidity of crushing proportion.
The proportion of systemic CL due to CRRT varied widely and was high in some cases.
Other inflammatory diseases such as scleritis have a higher proportion requiring systemic therapy, but are overall much less common.
