One tantalizing hypothesis, which arises from elegant mouse work, is that changes in local vascular permeability might provide a route via which a systemic autoimmune propensity becomes focused on the synovium [72].
The action of specific bacterial toxins causes the thrombophlebitis, which has the propensity of systemic complications and local circulatory effects.
We have a systemic problem in our propensity to treat science like a Ping Pong ball, pretending that the weight of evidence and our fundamental understanding change with each new study.
Ciclesonide, from a clinical standpoint, appears comparable to budesonide and fluticasone propionate, but with less propensity for systemic adverse effects.
Controversial results exist regarding the propensity of systemic proteasome inhibition to induce PD-like nigral degeneration in rats [ 18, 24, 26, 34, 46].
Among antidepressants, tricyclics (TCAs) and MAOIs have a propensity for systemic side effects (anticholinergic effects of TCAs may also further compromise cognition) and are best avoided.
In general, the propensity for systemic absorption of any orally consumed substance is inversely proportional to the size of the molecule, with smaller molecules more readily absorbed intact than larger ones (Gardner, 1988 ).
42 As a consequence of the low oral bioavailability of linaclotide combined with the restricted expression of GC-C, the pharmacological activity of linaclotide remains limited to the GI tract, resulting in a low propensity for systemic side effects.
Linaclotide, a first-in-class GCCA, is a promising new drug with a novel, dual mechanism of action that, unlike more well-established agents, can relieve the abdominal pain, bloating and constipation associated with IBS-C and has a low propensity for systemic side effects.
Yesterday I wrote about the Pentagon's dubious role in funding social science research that could be applied to active military operations in the context of the increasing propensity for global systemic crises to challenge US interests.
