Exact(4)
Hemophagocytic lymphohistiocytosis (HLH) is an uncommon syndrome characterized by a reactive, systemic proliferation of benign histiocytes throughout the reticuloendothelial system (1 ).
HLH is a disease characterised by systemic proliferation of histiocytes.
This approach has recently shown promising results in limiting the systemic proliferation of P. aeruginosa infection in mice (Lesic et al., 2007).
Reactive histiocytic hyperplasia with hemophagocytosis (HHH) is characterised by a systemic proliferation of non-neoplastic histiocytes with phagocytosis of hemopoietic cells.
Similar(56)
In addition, the inhibition of arginase did not alter systemic T-cell proliferation.
However, PTEN is a major regulator of the PI3K pathway involved in systemic cell proliferation, survival, migration and metabolism.
Spleen weight as a measure of systemic immune cell proliferation was also comparable between age- and sex-matched mice of both K14/IGF-1Ea and wild-type controls (Fig. 1E).
In addition to systemic effects, NSCs proliferation can also be influenced by cellular and molecular changes taking place within the neurogenic niche.
Estrogen has also been shown to decrease systemic T lymphocyte proliferation [ 35], and herein we confirm these results and establish that expression of ERα is required for the decreased conA-stimulated splenic T-cell proliferation.
Thus, this growth factor is a general promoter of systemic myeloma cell proliferation and survival, and antagonizing its biological effects is, therefore, predicted to aid antitumoral therapies at many sites of the body.
A pertinent finding is that HBO affected the proliferative capacity of HSCPs and MSCs in the young, but not in old mice, in line with the observation that systemic hyperoxia enhances proliferation of human (Thom et al. 2006) and murine BM-derived HSCPs (Thom et al. 2006; Milovanova et al. 2009).
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