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The OCT photoreceptor findings in this patient pre- and post-injection indicate that intravitreal steroids may be able to successfully suppress inflammation and apoptosis induced by the autoantibodies at the level of the photoreceptors despite ongoing systemic production and/or circulation of antibodies.
Sepsis and septic shock are associated with the systemic production of inflammatory cytokines [11] [14].
Even short periods of ischemia can induce the systemic production of various inflammatory mediators and activates leukocytes, which may lead to remote organ injury and subsequent mortality.
Thus, intravenous post-exposure MVA immunization induced a rapid strong innate and adaptive immune response as shown by the systemic production of cytokines and the activation of NK and T cells.
In Drosophila, several non-catalytic PGRPs function as selective peptidoglycan receptors upstream of the Toll and Imd pathways, the two major signalling cascades regulating the systemic production of antimicrobial peptides.
However, we still considered that the capacity for production of anti-inflammatory cytokines may have been modified although increased systemic production of anti-inflammatory cytokines, such as IL-10, was not detected.
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The high CSF/plasma ratios suggest that for some cytokines, activation within the CNS might have occurred along with respiratory-tract and systemic productions (cytokines are not detected in CSF normally; (Table 2) (4, 7 – 10, 12 ).
This is most probably a reflection of the inhibitory effect of apyrase on systemic TNF production, possibly aided by its negative effect on IL-1 β production.
Live, attenuated, oral poliomyelitis virus (Sabin vaccine) induces both local gastrointestinal and systemic antibody production; thus, immunization by mouth is preferred.
Markers of systemic RNI production are increased in the setting of systemic lupus erythematosus (SLE) activity.
Biocontrol agents protect plants from infections by phytopathogens (through competition for nutrients, induced systemic resistance, production of antimicrobial secondary metabolites).
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