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Else, it was shown that colistin trough plasma concentration significantly increased between days 2 and 3, suggesting colistin accumulation with time as a result of slow systemic passage through the alveolar capillary membrane [9].
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The experiments discussed here were carried out to indirectly measure the passage of systemic [HCO3−] excess from a single oral dose of sodium bicarbonate.
Although breast tumor xenografts had proven to be quite challenging, Visonneau and colleagues [ 1] transplanted 16 patient biopsies subcutaneously into etoposide-pretreated severe combined immunodeficiency (SCID) mice, achieving a 50% take rate with systemic spread and serial passage of two lines.
The GI tract damage and occurring microbial translocation might be hardly repaired by the late institution of therapy, in turn favouring the continuous passage into the systemic circulation of a highly polymicrobic intestinal flora.
While these experiments do not directly measure tumor pHe, they provide some characteristics about the rapid passage and diffusion of systemic [HCO3−] after an oral dose.
Since the pulmonary artery carries blood from all vascular beds of the organism, mixed venous blood may represent the amount of oxygen in systemic circulation that is left after passage through the tissues.
Mean arterial pressure – the lower the mean arterial pressure, the lower the intrauterine pressure required to cause passage of fluid into the systemic circulation.
Failure of the intestinal barrier from bacterial overgrowth and passage of lipopolysaccharide to the systemic circulation and uncontrolled stimulation of the inflammatory mechanisms probably also have a part to play.
Blood pressure in the systemic circulation has been shown to rise during passage of the blast pressure wave [ 28- 30].
Studies of the pulmonary translocation of model particles to systemic circulation and secondary organs indicate only minute passage (Kreyling et al. 2002; Mills et al. 2006; Möller et al. 2008; Wiebert et al. 2006).
The Fontan procedure was first introduced for patients with tricuspid atresia to allow systemic blood return to enter the pulmonary arteries without passage through a ventricle in 1968 by Fontan and Baudet [1, 2].
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