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Eight metabolites are at the boundary of the system and therefore act as systemic parameters and are referred to as "external metabolites"; the remaining nine are free, and called "internal metabolites".
In none of the experiments systemic parameters changed significantly during the infusions.
Moreover, TCD values could be biased by several systemic parameters, usually not controlled in these unstable patients.
Computer simulation results show that the proposed controller is very effective and robust against the uncertainty in systemic parameters.
For interpretation of ANN models, a means of evaluating how systemic parameters contribute to model output is essential.
Tolerance towards the effects of inhaled β2-AR agonists generally is more easily shown for systemic parameters than for airway effects and can be substantial.
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To demonstrate the power of such a bottom-up modeling approach combined with a systemic parameter determination, we used the simple and well understood photosynthetic apparatus of the purple bacterium Rhodobacter (Rb).
The results of the ocular and systemic parameter comparison are summarized in Table 3.
No statistically significant changes in the systemic parameter were found between the baseline and 6-month examinations.
One of the potential pitfalls of pHi calculation is that it includes arterial bicarbonate, which is a systemic parameter not dependent on gut perfusion.
In contrast, the direct pharmacologic inhibition of RANKL by OPG-Fc prevented local (joint) and systemic (vertebral) bone loss in both models, without inhibiting any measured local or systemic parameter of inflammation.
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