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After the systemic optimization we could then interpret the obtained optimal parameter values in the molecular realm.
We divided our cardiac differentiation system into four distinct phases for rigorous, systemic optimization (Figure 1A): phase 1, uniform undifferentiated hPSC growth; phase 2, hEB formation/mesoderm induction; phase 3, hEB cardiac specification; phase 4, contracting cardiomyocyte development.
The main part of the study describes the important steps required for the systemic optimization of building sustainability.
The Exergy Composite Curves approach is used within a systemic optimization framework to explore various complex ORC configurations.
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In a lactate-driven resuscitation protocol, Jansen et al. [7] recommended systemic flow optimization exclusively in hyperlactatemic patients with concomitant low central venous oxygen saturation (ScvO2).
The product service systems' (PSS) sustainability potential is described in the framework of the new types of stakeholder relationships and/or partnerships, producing new convergence of economic interests, and a potential concomitant systemic resources optimization.
Often these alterations persist after systemic hemodynamic optimization.
In the systemic multi-parameter optimization, however, such extreme settings are less favourable because they are more sensitive to small parameter changes and therefore effectively suppressed.
To best understand this shift, we need to look back at how electronics have developed, in four phases, with each transition separated by about 7-8 years from its predecessor: analog expansion, digital convergence, digital optimization and systemic integration.
Second-tier interventions to improve PbtO2 despite CPP modifications include optimization of systemic oxygenation (lung protective ventilation and maintenance of strict normoxia) [43] and red blood cell transfusion if hemoglobin is below 9 g/dl [44] (Figure 4).
The final result is an optimization of systemic perfusion (normal cardiac function is required for this supposition).
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