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S. aureus acquires heme-iron using the iron regulated surface determinant (Isd) system and the heme transport system (Hts) with both systems showing critical importance in systemic models of infection.
Comparisons with the serial implementation when running two programs at different scales show that as the number of systems increases, the parallel architecture is several hundred times faster than the existing implementations, making it feasible to investigate systemic models of more complex biological systems.
In addition, both the Hts and Isd systems are individually required for full virulence in systemic models of staphylococcal infection [2] [4] however their combined contribution to pathogenesis has not yet been elucidated.
Systemic models have the advantage of allowing the study of heterogeneous, complex karst systems without relying on extensive geographical and meteorological datasets.
The first two systemic models utilize standard ODE-based adipose compartments that assume rapid equilibrium and uniformity.
Here we compare the capacity of two systemic models to simulate the discharge and piezometry of a karst aquifer.
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Lastly, the methodology applied in the ATM domain presented in this paper is equally transferable to systemic modelling of other complex socio-technical systems.
This pools-and-proteins approach naturally compiles the wealth of available molecular biological data into a systemic model and can easily be extended to describe other systems by adding new protein or nucleic acid types.
A change in a small part of a complex network can affect the overall capabilities of a system, such as metabolite production, which can be impossible to predict without a systemic model.
Drayton Park, to use the jargon, follows a "systemic" model rather than a "medical" one.
But none completely explain behavior because deep down people have passions and drives that don't lend themselves to systemic modeling.
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