Sukhdev says: "Over-leverage or misuse of leverage has systemic risk implications, and yet, very few central banks regulate corporate leverage.
For example if the aggregate hospital accreditation data reveals a systemic problem with antibiotic overuse and misuse at a national level, policy changes might modify he national formulary and develop consistent clinical policies for appropriate antibiotic stewardship throughout the country.
The chronic misuse of the energy expenditure system leads to the known systemic disease sequelae in chronic inflammatory diseases (see below).
Deborah Coles co-director of Inquest, which investigates controversial deaths following police contact, said confidence in the Met was declining: "Our work on contentious deaths and their investigation has shown a systemic lack of accountability, transparency and institutional responsibility for abuse and misuse of police powers.
Most cases of WKS in developed countries relate to the misuse of alcohol, although WKS syndromes following gastrointestinal disorders and systemic diseases can also contribute.
Data subjects can be harmed by suboptimal care, distress, reputational damage, and more generally a loss of privacy resulting from misuses of data by public health professionals and researchers (Laurie et al. 2014 .4 Systemic impacts on medical practice and the doctor-patient relationship are normally difficult to predict (Chadwick & Berg, 2001; Coeckelbergh, 2013).
The National Union of Journalists has told parliament that police misuse of the Regulation of Investigatory Powers Act to snoop on journalists and their sources is "systemic and institutionalised" and is doing "irreparable damage" to the industry.
The absence of appropriate regulations and oversight have allowed the misuse and abuse of confidential informants to become an everyday occurrence in the "War on Drugs," breeding systemic injustice on a national scale.
"The misuse and abuse of prescription opioids is a complex public health challenge that requires a collaborative and systemic response that engages all stakeholders," said John Parker, a spokesman for Healthcare Distribution Alliance, a national trade association representing wholesale distributors including McKesson, Cardinal Health and AmerisourceBergen.
