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The ageing systemic milieu negatively regulates neurogenesis and cognitive function.
Moreover, WAT and liver from heterotypic WT parabiots metabolically remodel when subjected to the lean systemic milieu of MED13cTg mice.
Intriguingly, these experiments also hinted at a small but persistent inhibitory effect of the aged systemic milieu on the performance of young stem cells.
A similar phenomenon was noted in the ability of a young systemic milieu to rejuvenate aged oligodendrocyte precursor cells and promote remyelination of axons in old mice [ 11].
Results of these experiments suggest that satellite cells and liver progenitor cells of aged mice can be rejuvenated in vivo by exposure to a young systemic milieu.
Remarkably, the lean systemic milieu of MED13cTg mice is able to metabolically remodel WAT, liver and essentially whole-body metabolism in WT mice.
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The activation state of the systemic inflammatory milieu has been proposed as a critical regulator of vascular repair after injury.
Based on our in vivo studies, we suggest the following model (Fig. 6): in a first line of defence antiviral and Th1 inducing cytokines are produced that mediate a systemic antiviral milieu and activate NK cells.
Adiponectin and leptin however could represent an increased systemic inflammatory milieu from obesity [ 65, 66].
Recent studies suggest that circulating factors constitute a systemic aging milieu capable of regulating and coordinating tissue regeneration.
More importantly, NAF seems to reflect the impact of the systemic hormonal milieu on the breast tissue itself.
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