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To support Hagar's survival with son Ishmael, Sarah would have had to take a step away from her power, regardless of the systemic limits of that power.
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However, efficient systemic delivery limits clinical implementation.
The fact that existing kinetics parameters in the literature have been determined by parametric optimisation using a systemic model limits the reliability of the prediction of local concentrations and of the local design of activated sludge reactors.
The lack of increased YKL-40 in serum in the absence of systemic inflammation limits the benefit of this potential biomarker in early disease.
Accordingly, parathion "spares" developing neurites and cholinergic projections because its greater systemic toxicity limits the dose that can be given, rather than because it is inherently less neurotoxic (Slotkin et al. 2006).
The blood brain barrier and unacceptable systemic toxicity limit the employment of chemotherapeutic agents.
Cisplatin (CDDP) is an effective anticancer agent for many solid tumors but has significant systemic toxicity limiting its use in many patients.
Side effects of systemic analgesics limit their use on a regular basis [ 6, 7].
A lack of data on the individual level socioeconomic status and the administration of systemic therapies limited us from evaluating these factors as potential confounders.
Targeted therapies, by their very nature of being 'targeted', are not associated with the systemic, dose limiting toxicities seen with traditional cytotoxic chemotherapy agents.
The PCT ROC curves for evolution to death as a result of systemic infection limit an area under the curve statistically different than that expected by chance, whereas this is not the case for CRP.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com