Sentence examples for systemic limitations including from inspiring English sources

Despite the therapeutic potential of RNAi molecules, systemic limitations including short circulatory stability and low release into the tumor tissue have halted their progress to the clinic.

Although many adjuvants have been proposed over the last few decades, the vast majority have not been successful in being approved for human use, with limitations including unacceptable local or systemic toxicity, manufacturing difficulties, instability, and prohibitive cost [ 18, 19].

In addition, the systemic administration of neuroactive biomolecules in order to stimulate neuronal regeneration has several limitations including toxicity and poor stability associated with many bioactive factors [1].

However, this drug has some pharmacokinetic limitations including unfavorable maximum drug concentrations (Cmax) and short half lives following systemic bolus injection.

The strict eligibility criterion to be treatment-naive at study entry presents several limitations, including the potential overrepresentation of children with mild disease, as evidenced by the lack of patients with systemic arthritis in our study population.

Other limitations include systemic toxicity and poor penetration into ischemic or necrotic tissues.

These limitations include large volume of distribution leading to systemic toxicity of vital organs, low blood flow into interior of a tumor site resulting in inability to provide optimal dose, and frequent dose reduction due to various toxicities like hematologic, neurologic, and physiological.

Study limitations include self report of race.

Other limitations include the following.

Major limitations include the following.

Limitations include its retrospective nature.