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'systemic involvement' is a correct and usable term in written English.
You can use it when you are referring to the participation of different elements within a larger system. For example, "The project required a high degree of systemic involvement between the relevant parties."
Exact(60)
Systemic involvement mainly affected the patients' skin (hyperpigmentation, hyperkeratosis), nervous system (polyneuropathy, tremors, headache), and GI system (gastroenteritis, toxic hepatitis).
He said there had been "systemic involvement" in the letter by senior BBC management including Cohen and others.
Systemic involvement was seen in one case.
Systemic involvement with high temperature is uncommon.
Table 3 Systemic involvement in lupus retinopathy Patient no.
Its systemic involvement of lungs, heart, diaphragm, liver or kidneys can vary.
SLE is a chronic autoimmune disease with a heterogeneous course and systemic involvement.
A provisional diagnosis of multiple choroidal granulomas with systemic involvement was considered.
Following this, case reports of similar findings and also significant systemic involvement found on autopsy were reported [5, 6].
Systemic involvement (e.g., lung fibrosis and kidney failure) tends to be less severe than in systemic sclerosis.
No systemic involvement occurred in our patient; however, this reaction was limited to the deterioration in visual functions.
More suggestions(14)
systematic involvement
pervasive involvement
systemic implication
structural involvement
widespread involvement
comprehensive involvement
institutional involvement
generalized involvement
systemic commitment
structured involvement
system wide involvement
arrangements involvement
institutions involvement
system involvement
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com