These data suggest that the K/BxAg7 mouse is a novel system for investigating the interplay between systemic inflammation occurring in RA and the development of atherosclerosis.
An experimental setup that enables the isolation of each one of the kinematic parameters and the systemic study of their interplay is employed.
The interplay between systemic inflammation and hyperoxic damage is complex and possibly dependent on the temporal relation of events [28 30].
Mammary gland development occurs mostly postnatally and is dependent on a complex interplay of systemic hormones and local growth factors [1], [2], [3].
OA is normally the result of an interplay between systemic (e.g. age, obesity) and local (e.g. sports injury) factors that affect the joints of the body.
It should not be ignored that this approach disregards the possible interplay of systemic immune cells which undoubtedly also play a major role in anti-tumor immunity.
Postnatal development of the mammary gland involves ductal and secretory phases that are regulated by concerted interplay of systemic hormones, locally secreted growth factors, and their receptors – including the EGFR family, which plays a major role [ 38, 39].
The HF approach views causation of critical incidents and unplanned events in clinical practice as being a complex interplay between systemic and environment factors in the workplace and various well described (and normal) limitations in human performance, rather than being 'errors' made by blameworthy individuals.
Molecular clonality studies of haematopoietic reconstitution in gene therapy of SCID-ADA may thus provide substantial biological information on the speed and kinetics of lymphatic cell regeneration, the clonal complexity of haematopoiesis at the systemic level and the interplay of vector and host features on the cellular level.
In order to understand the interplay between systemic inflammation that occurs in RA-like disease and atherosclerosis, we generated mice (K/BxAg7) that express the KRN TCR transgene (K), and the MHC class II Allele H-2k (Ag7), which were backcrossed for several generations onto a C57BL/6 (H-2b) background.
Systemic delivery involves a complex interplay of drug properties and physiological factors, and heterogeneity in the tumor microenvironment makes predicting and overcoming these limitations exceptionally difficult.
