Sentence examples for systemic generation from inspiring English sources

Since pregnancy is known to favor systemic generation of reactive oxygen species, this study was designed to assess the levels of exhaled hydrogen peroxide (eH2O2), serum progesterone (PG), 17β-estradiol (E2) and systemic oxidative parameters in 20 pregnant women between 15th and 28th gestation week and 23 healthy, eumenorrheic women.

Several mechanisms might be involved in the induction of this effect of adalimumab plus MTX on circulating monocytes, including modulation of cell trafficking, monocyte survival and/or systemic generation from bone marrow precursors.

Other studies have shown that extrahepatic sources of CRP production from adipocytes could point to a more systemic generation of CRP in the body after stimulation by inflammatory cytokines and more specifically, by the adipokine, resistin (1).

The rationale for this adjunctive treatment strategy is based on the notion that natural anticoagulant pathways are defective in patients with a severe systemic inflammatory response upon infection and that this may play a central role in the systemic generation of thrombin and subsequent formation of microthrombi, which may contribute to the pathogenesis of organ dysfunction [ 2, 3].

Although local administration of rh-aPC, plasma-derived AT or heparin did not affect systemic thrombin generation, nebulized danaparoid reduced systemic thrombin generation.

Their first study showed marked systemic thrombin generation due to circulating procoagulants that initiate thrombin generation systemically as well as a reduced ability to localize hemostasis at the wound site due to the loss of antithrombin.

Severe organ failure appeared as a major determinant of early circuit clotting due to prior systemic thrombin generation with consumptive coagulopathy, heparin resistance and elevated extracorporeal thrombin generation.

However, we found that early circuit clotting was associated with more severe organ failure, prior systemic thrombin generation with consumptive coagulopathy, heparin resistance and elevated extracorporeal thrombin generation.