"Women most often have vaginal irritation but a notable few have systemic flu-like symptoms, and a rare few have potentially deadly anaphylaxis," he said.
More frequently systemic flu-like symptoms occurred: fever or painful swelling of the injected lymph node (after intranodal injection).
Treatment with IL-12 was associated with systemic flu-like symptoms (fever, chills, fatigue, arthromyalgia, headache) and more difficult to control toxic effects on the bone marrow and liver.
Other bacterial pathogens, such as those causing anthrax (B. anthracis) or plague (Yersinia pestis), induce systemic, flu-like symptoms initially and progress to lethal shock and death days later.
The most common systemic adverse events were flu-like symptoms consisting of fever, myalgias, hypotension, and headache.
The occurrence of local (e.g. hematuria and LUTS) and systemic (e.g. flu-like symptoms) side effects were both significantly elevated by maintenance therapy.
The most common reported adverse reaction of systemic interferon was a flu-like syndrome, which was defined as the simultaneous occurrence of two of the following: fever/chills, headache, malaise/fatigue, and myalgia/muscle aches.
The definition of mastitis is the development of at least two breast symptoms (pain, redness, lump) and at least one systemic symptom (fever or flu-like symptoms) [ 3, 27].
Brief, self-limited injection-related reactions, either local reactions (for example, redness, induration or swelling) or systemic reactions (such as flu-like symptoms, fever, headache, fatigue, chills or muscular pain), were observed in the majority of patients receiving CAD106.
For this analysis the definition of mastitis was the development of at least two breast symptoms (pain, redness, lump) and at least one systemic symptom (fever or flu-like symptoms) [ 1, 32] or treatment of mastitis with antibiotics.
They were referred to our laboratory by lactation consultants and midwives attending different health-care centers in Spain and all cases included either both local (breast redness, pain and engorgement) and systemic symptoms (fever or flu-like symptoms) or only local symptoms (pain, engorgement, reduced milk secretion).
