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Systemic factors such as viral proteins or cytokines could be engaged in lymphoid tissue response [7, 18].
Host staging for comorbid issues included systemic factors such as HIV infection and CD4 count as well as any chronic medical conditions.
Each was explored across 10 systemic factors such as citizens' expectation, markets, governance and institutions, science and technology and so on creating a matrix with 340 cells.
Although localized to the mineralized matrix of bone, osteocytes are able to respond to systemic factors such as the calciotropic hormones 1,25(OH)2D3 and PTH.
We take conservatism to refer to explicit or implicit, cultural, social and often systemic factors, such as the curriculum, that happen to be dominant or held in high esteem in a given society, and which are generally taken for granted with an appeal to tradition or habit.
CNS damage is believed to activate local factors such as bone morphogenic protein or systemic factors such as prostaglandin E2, or both [1], [4], [6].
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We also examined the temporomandibular joint to determine whether a systemic factor, such as adipose-associated inflammation, contributes to the increased incidence of osteoarthritis at nonweight-bearing sites.
Regarding the skeletal mechano-responsiveness per se, both systemic factors (hormones such as estrogen and growth hormone) [5] [12] and local factors (growth factors such as insulin-like growth factor 1 and 2) [14], [14] have been shown to have a direct modulatory effect.
Similarly, antagonizing systemic proinflammatory factors such as interleukin-1 [ 263] or TNF-α [ 264; 265] also showed therapeutic effects against T2D.
Other systemic risk factors such as hyperlipidemia, cardiovascular diseases, blood hyperviscosity and diseases with hypercoagulation were not studied.
Current effective interventions for DME include treatment of systemic risk factors, such as elevated blood glucose, blood pressure and dyslipidemia.
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