Sentence examples for systemic exposures from inspiring English sources

The low systemic exposure seen in these studies raises the question as to whether greater melphalan doses could be used in the system, thus allowing for greater liver/tumor exposure while potentially maintaining or decreasing systemic exposures seen in clinical trials.

A second goal is to inform in vitro strategies as to relevant dosing (potency) levels at the cellular level that reflect realistic systemic exposures.

However, systemic exposures were markedly lower at Week 13 compared to that observed at Week 4, suggesting induction of metabolism or reduced absorption from the gastrointestinal tract following oral dosing.

There were several challenges related to selecting doses for atorvastatin, including understanding the dose exposure relationship from different drug forms used by the innovator in their general toxicology studies, bioanalytical assays that did not separate and quantify parent from metabolites, and high variability in the systemic exposures following oral dosing.

The plasma exposures correspond to lung depositions with the evidence of reduced systemic exposures.

Defining the relationship between selinexor systemic exposures in mice and humans will be important in assessing the clinical relevance of these results.

The overall systemic exposure of des-CIC was low.

No gender difference in systemic exposure of KH176 and KH176m was observed.

Following repeated dosing, no marked accumulation in systemic exposure of KH176 and KH176m was observed at any dose level.

Intravesical administration of targeted nanoparticles can reduce systemic exposure, but for clinical use, nanoparticles with established biosafety profiles should be used to decrease long-term toxicity in cases where systemic exposure occurs.

Compared with sucrose, HFCS leads to greater fructose systemic exposure and significantly different acute metabolic effects.