The overall systemic exposure of des-CIC was low.
No gender difference in systemic exposure of KH176 and KH176m was observed.
Following repeated dosing, no marked accumulation in systemic exposure of KH176 and KH176m was observed at any dose level.
Intravesical administration of targeted nanoparticles can reduce systemic exposure, but for clinical use, nanoparticles with established biosafety profiles should be used to decrease long-term toxicity in cases where systemic exposure occurs.
Compared with sucrose, HFCS leads to greater fructose systemic exposure and significantly different acute metabolic effects.
Systemic exposure to drugs, chemicals and foods can cause abnormally colored urine.
Here, we examined the effects of a LXR antagonist/inverse agonist, GSK2033, which displays systemic exposure.
Additionally, the systemic exposure of ABZ metabolites was assessed in those ABZ-treated infected animals.
The absolute oral bioavailability is high (90.9%), indicating a clear systemic exposure.
Once you factor in the systemic exposure of U.S. homeowners, the losses in asset values predicted by existing financial models correspond closely to the losses actually realized.
KH176m to KH176 ratios in systemic exposure on Day 1 and Day 28 ranged from 0.67 to 0.97 in dogs and from 0.055 to 0.091 in rats.
