However, despite significant advances in genomic sciences in identifying oncogenes and tumor suppressors, a systemic explanation of how these genes deregulate the normal function of genetic circuits and how its control may be used to design effective drugs against cancer still remains a great challenge in systems biology [2], [3], [4], [5], [6].
German thinkers often skirted the issue of Hitler, preferring systemic explanations.
The term-limit idea at least has the virtue of recognizing, however dimly, that there are systemic explanations as well as moral ones for our collective woes".
The public fascination with term limits, the line-item veto--whatever one may think of the merits of those proposals shows that voters are willing to consider systemic explanations as well as moralistic ones for their government's manifest failures.
Learning and human development in general call for systemic explanations (Thelen & Smith [1994]).
Under this broad theoretical umbrella, single-factor or multifactorial explanations of everything from motor skills to the rise and collapse of civilizations are giving way to systemic explanations in which outcomes are seen as emergents of self-organizing processes among lower-order components.
This indicates that the circadian clock model contains more non-monotonicity or other complex nonlinear relationships between parameters and behaviour, but the systemic explanations are not easy to pinpoint as both dynamic models contain complex wiring.
Such an iteration system or something very much like it, was introduced as a systemic functional explanation of the difference between the concept of 'text complex' (Hasan, [1999]: 28 4773; [2000]: 28–47) and Martin's 'genre combination'.
Neurogenic switching is a possible explanation for systemic anaphylaxis, in which inoculation of the skin or gut with antigen produces systemic symptoms involving the respiratory and circulatory systems, and an experimental model of anaphylaxis is consistent with this hypothesis.
The reduction in plasma epinephrine concentration by TEA represents a plausible explanation, while systemic effects of the local anesthetic as a further potential mechanism could not be excluded.
Finally, the autophagic tumor stroma model can also provide an explanation for systemic cachexia, which is progressive skeletal muscle and adipose tissue wasting, affecting up to 50% of all cancer patients and resulting in severe weight loss and shortened survival [ 94].
