Sentence examples for systemic expansion from inspiring English sources

Hence, systemic expansion of CD4+CD25+ T-lymphocytes may add on the concept of immune system pregnant-related suppression and might support the better clinical MS pregnancy course.

Detailed recent studies designed to delineate the mechanisms of tumor cell IDO-induced immunosuppression showed that the effect of IDO in the tumor microenvironment is mediated through increased differentiation of Treg cells at the tumor site, systemic expansion of myeloid cells and marked recruitment of myeloid-derived suppressor cells (MDSCs) into the tumor microenvironment [179].

Here, we review nanotechnology-based approaches designed to promote immune tolerance through various mechanisms, ranging from systemic or local suppression of antigen-presenting cells and deletion of antigen-specific T-cells, to the systemic expansion of antigen- and disease-specific Treg cells in vivo.

Pregnancy itself induces a systemic expansion of the pool of regulatory T cells that starts already prior to implantation and is independent of exposure to alloantigen [4].

One way to achieve this would be by increasing the likelihood of regulatory T cells encountering paternal alloantigen, by systemic expansion of their number towards estrus [9] and by increasing their presence in the uterus in preparation for implantation.

Suppressor neutrophils are detectable in patients with GCA and their systemic expansion is apparently modulated by steroid therapy.

All types of fluid media can potentially cause complications where there is rapid systemic absorption, expansion of the systemic circulation leading to pulmonary oedema and heart failure.

Cardiovascular and renal disease – those women with known cardiovascular disease, renal impairment and the elderly are less likely to adapt to sudden significant increases in intravascular fluid such that complications from systemic fluid expansion and electrolyte imbalance are more likely at lower levels of fluid deficit [11].

Although metastasis is important for systemic tumour expansion, it is a highly inefficient process, with millions of cells being required to disseminate to allow for the selection of cells aggressive enough to survive the metastatic cascade (Chambers et al, 2002; Gupta and Massagué, 2006).

Institution of mechanical ventilation, volume expansion, systemic alkalinisation (pH 7.51), and intermittent bolus metaraminol resulted in QRS narrowing but failed to resolve the developed shock.

We considered that mutations at the S1/S2 site could alter proteolytic cleavage and modify S fusogenic properties, leading to tropism expansion, systemic spread and, ultimately, FIP.