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Alternatively, age-related changes that occur in local and systemic environments might be responsible for the decline in neurogenesis.
To assay the affects of heterochronic local and systemic environments on stem cell regenerative potential, hESC, hMSC, and myofiber-derived precursor cell cultures were fixed with 70% EtOH/PBS at 4 °C, and were analyzed by indirect immunofluorescence.
Efforts to overcome the ongoing health inequities amongst Indigenous peoples should involve understanding the contextual determinants of health and the interactions between these broader systemic environments and individuals' responses to these circumstances (15, 23, 109).
4) In the Discussion, it is stated: "Further experiments will need to be performed to examine the contribution of acidic pH and divalent cation sensing to PhoQ-mediated bacterial survival during transition from the intestinal tract to systemic environments and determine if 'bacterial innate immunity' or the recognition of multiple mammalian signals is redundant".
Further experiments will need to be performed to examine the contribution of acidic pH and divalent cation sensing to PhoQ-mediated bacterial survival during transition from the intestinal tract to systemic environments and determine if 'bacterial innate immunity' or the recognition of multiple mammalian signals is redundant.
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In contrast to Hill equations, which are not available for enzymatic reactions, which only calculate relative concentrations, and which only work for one reaction in isolation, the psf system calculates enzymatic and complex formation reactions in a complex systemic environment using absolute concentrations.
In a mouse model of young and old mice sharing the circulatory system (heterochronic parabiosis model) aged SCs were rejuvenated by exposure to a young systemic environment suggesting that the tissue-specific stem cells retain their proliferative potential, but that the aged systemic environment prevents full activation.
This hypothesis has been clearly validated by parabiotic experiments, the union of two organisms that share the circulatory system, demonstrating the rejuvenation of aged progenitor cells by exposure to a young systemic environment (Conboy et al. 2005).
LbL assembly of polypeptides effectively prevented exposure of PTX to the systemic environment and thereby inhibited drug-induced hemolysis.
I have not replicated this practice here: the terms, having been embedded in a largely new systemic environment, no longer mean the same thing.
They aim for a multidimensional function design striving to address the demands of the local and systemic environment, in addition to patient comfort and quality of life.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com