General systems theory [35] provides a conceptual framework within which systemic entities can be organized.
An additional aspect of systemic organization that should be briefly mentioned is that systemic entities show emergent properties through self-organization, including feedback control and mechanisms of self-regulation.
Unlike the broader class of mechanistic mathematical models describing how complex biological phenotypes arise from the interactions of lower-level systemic entities, cGP models are distinguished by linking together (cohering) the individual's genotype and its phenotype in a causal mathematical structure.
7– 9 IAC represents the biliary manifestation of a fully separate systemic disease entity: IgG4-related disease (IgG4-RD).
IBD has been long ago recognized as a systemic inflammatory entity and as such, it is anticipated to induce changes exceeding the boundaries of bowel mucosa, being reflected in a broader spectrum of tissues, including blood [ 16- 19].
Two years ago, Gary Gensler, then under secretary of the Treasury for domestic finance, startled the bond markets when he testified in Congress about the potential systemic risk these entities posed to taxpayers.
"Such a dramatic intertwining of the industrial economy and supply chain with the financial system creates systemic risk, since there is effectively no regulatory entity that can oversee what is happening within these sprawling global entities".
Then, as a result of tissue damage, disruption of the mucosal barrier and access to the systemic circulation of toxic entities occurs.
A major point of agreement is the need for a new entity to detect systemic risks and prevent them from damaging the financial system.
House Financial Services Committee Chairman Barney Frank has said the first priority in overhauling financial regulation is to set up an entity to oversee systemic risks of the kind that wreaked havoc on Wall Street last year.
