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Low-dose vaginal estrogen is an effective treatment for this symptom with negligible systemic effects.
Fromenti, S. & Demaria, S. Systemic effects of local radiotherapy.
There may be other systemic effects also causing general relaxation.
Just because systemic effects are difficult to quantify does not mean that they are not real.
Patel K, Cheshire D, Vance A. Oral and systemic effects of prolonged minocycline therapy.
Karastergiou, K. & Fried, S. K. Multiple adipose depots increase cardiovascular risk via local and systemic effects.
Barbu, C., Iordache, M. & Man, M. G. Inflammation in COPD: pathogenesis, local and systemic effects.
Locally administered FG-4592 does not promote inflammation or exert systemic effects.
Adamopoulos, C. et al. Systemic effects of AGEs in ER stress induction in vivo.
Both local and systemic effects are described in this section.
Several systemic effects have been described after talc pleurodesis.
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