Sentence examples for systemic drawbacks from inspiring English sources

Though not an easy task, this would permit to study BM formation or stability and epidermal barrier function in adult animals avoiding the deleterious systemic drawbacks.

Anthracyclines are effective anticancer drugs but have drawbacks including systemic toxicity and drug resistance.

In addition, there are pharmacologic hypoxia-mimetics available that can replicate the hypoxia-effects without the potential drawbacks of systemic hypoxia.

Targeting the lowest possible dose of the progestin or of the natural hormone progesterone to be delivered directly to the uterus, the target organ for which it is designed, would avoid the possible drawbacks of systemic effects of progestins on other targets.

Additional drawbacks are systemic hypotension and the high costs.

These features in combination with hepatic and systemic toxicity are major drawbacks toward wide clinical application.

We supposed that the drawbacks of systemic IL-2 application might be overcome by local IL-2 application.

Although speculative regarding the feasibility and efficiency, plastic material for example, particles or needles loaded with the PS directly inserted into tumors might represent a new approach of delivering this photosensitizing substance to the target tissue without the drawback of systemic photosensitization.

Perhaps the drawback of peptide delivery systems lies in systemic administration where accumulation in the liver is a frequent event.

However the drawback is the accompanying systemic toxicity, which targeted treatments may overcome.

However, the recurrence rate is high and the current treatments have the drawback of inducing strong systemic toxicity or causing painful cystitis [ 4].