Sentence examples for systemic dosing from inspiring English sources
The ability to achieve high, local concentrations of drugs or image contrast agents at a target site provides the opportunity for improved system performance and patient outcomes along with reduced systemic dosing.
However, due to the narrow therapeutic window and considerable side effects associated with systemic dosing, Prialt is only administered intrathecally.
To simulate systemic dosing, 1 mg/ml of tenofovir was added to the basolateral side of the tissue explant cultures.
When used to simulate systemic dosing (basolateral application), the drug is effective in preventing HIV-1 infection of the ectocervical and colorectal tissues.
To determine whether topical and systemic dosing could be modeled in explant cultures and if both are effective against HIV-1, ectocervical and colorectal explant cultures were set-up as described [29], [30].
Further, our polarized model also allows us to simulate systemic dosing of drug by applying tenofovir (1 mg/ml) to the basolateral side of the tissue (lamina propria) and HIV-1 to the apical side of the tissue (epithelium).
To test the involvement of VEGF165 in hypoxia-induced LV dilatation, normoxic chick embryos received a daily systemic dose of rhVEGF165 (R&D Systems, 50 or 100 ng/day) between E10 and E19.
This is particularly relevant given the current availability of low-dose long-acting progestogen only contraceptive such as the levonorgestrel-releasing intra-uterine system (Mirena) which delivers high local but low systemic doses of progestogen and offer highly effective contraception.
Although some ingredients in PTMC products might cause adverse reproductive effects at high systemic doses, these doses are hundreds to thousands fold greater than those systemically available from topical use at the recommended maximum dose (i.e. 10 g/day).
Food application results in much larger systemic doses than application as personal care products for most natural ingredients considered here.
To counteract resistance, which lowers the efficiency of cisplatin significantly, very high systemic doses of cisplatin are administered.
