Today, patients with pulmonary embolism, strokes, heart attacks and other types of acute thrombosis leading to near-complete vascular occlusion, are most frequently treated in an acute care hospital setting using systemic dosages of powerful clot-dissolving drugs.
Moreover, conventional systemic dosages may not provide adequate tissue concentrations against more resistant organisms, such as coagulase-negative staphylococci [7].
Therefore, the efficiency of this drug is related to its mucosal concentration and systemic dosages remain low after oral or rectal administration (20).
With higher systemic dosages, possibly necessary to have sufficiently high concentrations in the lung, without doubt the incidence of bleedings would rise.
Although it is standard to use induction chemotherapy followed by radiotherapy, there are some arguments favouring concurrent chemoradiation using chemotherapy at systemic dosages (Eberhardt et al, 1998; Jeremic et al, 1999) or at radiosensitising dosages (Trovo et al, 1992; Schaake-Koning et al, 1994; Bardet et al, 1997; Clamon et al, 1999).
We stopped topical dorzolamide/timolol combination and reduced systemic corticosteroid dosage.
At inclusion, the following data were recorded: year of disease onset, previous and concomitant DMARD treatment, and systemic prednisolone dosage.
In all ELS devices, heparin-coated cannulas and circuits were used to decrease the systemic heparin dosage and to reduce post-traumatic bleeding complications [ 18].
The Margin of Safety (MoS) of substances in a finished cosmetic product is derived by dividing the nonobserved adverse effect level (NOAEL) by the systemic exposure dosage (SED).
