This would allow neuroscientists to take a novel, systemic, discovery-focused approach to science, relating molecules to neurons and on to neural circuits and behavior, she says.
Though this is a task much more complex than the single-target strategy, major informatics resources and computational tools for the systemic approach of drug discovery are already set forth and their rapid progress forecasts promising outcomes for neuropharmacology.
This knowledge would pave the way for a conclusive interpretation and validation of systemic immune mediators and the discovery of a serological marker for asthma or asthma phenotypes or severity respectively.
A diagnosis of filariasis bancrofti infection was made after the discovery of a systemic hypereosinophilia.
Biomarker discovery based on systemic molecular signatures represents a promising strategy.
Animal screens also have the potential to eliminate compounds with systemic toxicity earlier in the discovery process.
The discovery that a systemic human ribonuclease binds to a moiety displayed on human cancer cells links two clinical paradigms and suggests a mechanism for innate resistance to cancer.
MRA was once considered ideal for patients with renal failure, but after the discovery of nephrogenic systemic fibrosis in patients with renal dysfunction receiving intravenous gadolinium, the initial enthusiasm drastically decreased.
Unfortunately, the discovery of nephrogenic systemic fibrosis and its probable association with gadolinium accumulation in renal failure (acute or chronic) [ 44] greatly limits its interest in AKI and critically ill patients.
Because the effects of many cancer therapeutics are systemic, employing a systems-based approach would efficiently facilitate circulating biomarker discovery in ACIC.
Understanding how circadian timekeeping occurs at the molecular level could inform new strategies for therapeutic discovery that aim to reinforce circadian systemic synchronization for its numerous health benefits.
