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However, finding a safe and effective systemic delivery system is the major obstacle in this area.
On the other hand, gene-based drugs have presented interesting challenges for systemic delivery systems.
A cationic lipid-based nanoparticle system reflects a novel systemic delivery agent for miRNA.
application but also the systemic delivery of the enzyme/prodrug system.
But some systemic delivery is now being tried.
However, efficient systemic delivery limits clinical implementation.
Ferguson, M. S., Lemoine, N. R. & Wang, Y. Systemic delivery of oncolytic viruses: hopes and hurdles.
However, systemic delivery of recombinant cytokines results in serious, potentially life-threatening, adverse effects.
Kaczmarek, J. C. et al. Polymer lipid nanoparticles for systemic delivery of mRNA to the lungs.
Roy, D. G. et al. Programmable insect cell carriers for systemic delivery of integrated cancer biotherapy.
Akinc, A. et al. Development of lipidoid siRNA formulations for systemic delivery to the liver.
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