systemic defect

USAGE SUMMARY

The phrase "systemic defect" is correct and usable in written English.
It can be used to describe a flaw or issue that is inherent to a system as a whole, rather than being isolated to a specific part. Example: "The investigation revealed a systemic defect in the software that affected all users."

✓ Grammatically correct

Science

News & Media

Encyclopedias

Human-verified examples from authoritative sources

Exact Expressions

7 human-written examples

Although its pathogenesis is complex, we have recently shown that CD patients have a systemic defect in macrophage function, which results in the defective clearance of bacteria from inflammatory sites.

Plosone

Growth retardation may result from a systemic defect in hormonal regulation, DNA double-strand break repair, or other causal mechanisms.

Breast Cancer Research

To determine whether MGL1−/− mice had a systemic defect in innate activation, we examined the responsiveness of macrophages from MGL1−/− mice to proinflammatory stimuli.

BioMed Research International

A systemic defect in mitochondrial complex I is implicated in PD, and its pathological features have been reproduced by chronic exposure of mice to rotenone, a pesticide that specifically inhibits complex I [ 6].

BMC Physiology

Altogether, these data agree with the hypothesis that OC(D) joint specificity is due to the interaction of different molecular mechanisms, which are altered in all joints (systemic defect) but trigger a different susceptibility (joint specificity due to the different biomechanical constraints sustained by the joints).

BMC Genomics

I expanded this portion into suggesting that the systemic defect, such as glucocorticoid deficiency, can both make a seemingly promising drug to go further into clinical studies and subsequently rejected, as well as, more importantly, make an actually promising drug to fail in animal studies, and thus prevent it from crossing the translational divide.

Biology Direct

Human-verified similar examples from authoritative sources

Similar Expressions

53 human-written examples

In their view, Wukan's uprising highlighted systemic defects in China's local governments, and only a housecleaning — not an isolated slap on the wrist — will address them.

The New York Times

Severe anomalies of the penis are rare and are generally associated with urinary or other systemic defects that are incompatible with life.

Encyclopedia Britannica

"Councillor Lambert was saying that, in his opinion, the children are not properly protected, and that this lack of protection is a consequence of legislative and systemic defects".

BBC

WASHINGTON, July 15 (Reuters) - The World Bank has systemic defects in its procedures to ensure that people and the environment are not harmed in development projects, according to an internal review obtained by Reuters.

Huffington Post

The first speaks to the glaring need for leadership development at all levels of an organization; the other to the reluctance to add full-time employees to payrolls for positions that may be better served by outside professionals - if they are empowered to provide their specialized skills without being absorbed into an organization's systemic defects.

Huffington Post

Expert writing Tips

Best practice

When using "systemic defect", ensure the context clearly indicates that the defect affects the entire system or a significant portion of it. Avoid using it for isolated or minor issues.

Common error

Avoid using "systemic defect" to describe isolated incidents or minor issues. This phrase implies a widespread problem, so ensure the scale of the defect justifies its use.

Linguistic Context

The phrase "systemic defect" functions as a noun phrase. It typically serves as the subject or object of a sentence, describing a flaw or problem inherent to a system. Ludwig AI confirms its usability in written English.

Expression frequency: Uncommon

Frequent in

Science

50%

News & Media

28%

Encyclopedias

6%

Less common in

Formal & Business

0%

Reference

0%

Social Media

0%

Ludwig's WRAP-UP

The phrase "systemic defect" is a noun phrase used to describe a fundamental flaw affecting an entire system, as confirmed by Ludwig AI. Predominantly found in scientific and news contexts, it denotes a widespread issue rather than an isolated incident. Related phrases include "widespread flaw" and "pervasive problem". When employing this phrase, ensure the issue's scale warrants its use. While grammatically sound and widely accepted, misuse in minor contexts is a potential pitfall. Ludwig's examples underscore its formal register and its suitability for analytical writing.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

widespread flaw

Emphasizes the broad reach of the flaw.

pervasive problem

Highlights the extensive nature of the issue.

fundamental deficiency

Indicates a basic or essential shortcoming.

inherent weakness

Suggests a weakness that is naturally part of the system.

structural fault

Focuses on a flaw in the system's structure.

system-wide failure

Highlights the complete breakdown of the system.

endemic issue

Implies the issue is consistently present and difficult to eliminate.

global malfunction

Emphasizes a widespread operational failure.

comprehensive breakdown

Highlights a complete and extensive failure.

deep-rooted problem

Suggests that the issue is deeply embedded and difficult to resolve.

FAQs

How can I use "systemic defect" in a sentence?

You can use "systemic defect" to describe flaws or issues that affect an entire system. For example: "The investigation revealed a "systemic defect" in the software that affected all users."

What are some alternatives to "systemic defect"?

Alternatives include "widespread flaw", "pervasive problem", or "fundamental deficiency", depending on the nuance you want to convey.

Is "systemic defect" formal or informal language?

"Systemic defect" is generally considered neutral to formal, suitable for professional, academic, and news contexts. It is less common in casual conversation.

What's the difference between "systemic defect" and "isolated problem"?

A "systemic defect" affects the entire system or a large portion of it, while an "isolated problem" affects only a specific part or instance. The former suggests a fundamental flaw, while the latter indicates a localized issue.