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Hyaluronidases contribute to local and systemic damages after envenoming, since they act as spreading factors cleaving the hyaluronan presents in the connective tissues of the victim, facilitating the diffusion of venom components.
Such moving targets on identification of specific and evolving mutations that are bases of the drugs (e.g., potent apoptotic factors or monoclonal antibodies against specific enzymes) that patients are treated with, are highly toxic and cause severe immunobiological and systemic damages to the normal functioning of tissues/organs, rather than being curative for patients.
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Would this failure cause systemic damage to the financial system?
Ideally, apoptosis induction should be restricted to selected organs or systems and adequately controlled to avoid fatal massive systemic damage.
The bigger issue is whether the country can afford the systemic damage being done by the ever-growing income inequality between the wealthiest Americans and everyone else, whether poor, middle class or even rich.
The effects of the lesion are complex, being related to the presence of a bacterial infection in the body, local damage to the valve, and systemic damage caused by fragments of a blood clot that breaks off and travels through the bloodstream to distant organs.
The company's weak sales of consumer products in the United States "could potentially signal some systemic damage to J.& J.'s brand name in light of the recent McNeil recalls and negative publicity," Rick Wise, an analyst with Leerink Swann, wrote in a note Tuesday to investors.
On July 21st, a month after the FSA intervened, the shares in HBOS, Britain's biggest mortgage lender, languished below the price at which the bank was trying to sell new equity, forcing it to rely on its underwriters.Some may say that the rules should still be bent to prop up bank shares, because banks rely on confidence and their failure causes systemic damage.
Ventilator-induced lung injury (VILI) has been related not only to pulmonary injury but also to systemic damage.
Moreover, the biochemical alterations and histopathologic injuries due to MMF administration were similar to aspirin-induced local disorders rather than to lipopolysaccharide-induced systemic damage.
Most of the evidence for the role of complement in preventing systemic damage comes from experimental data obtained in these studies in which the addition of complement inhibitors blocks or reduces damage [49].
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CEO of Professional Science Editing for Scientists @ prosciediting.com