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Systemic concentrations of markers of the tissue factor/FVIIa system and the contact system did not change during CVVH.
Systemic concentrations of markers of the tissue factor system and of the contact system did not change during CVVH.
Space- and time-varying lumen concentrations are predicted, as are time-varying systemic concentrations following introduction of the bolus.
One potential benefit of lower systemic concentrations is a reduced incidence of adverse events, such as nephrotoxicity [27].
Comparisons with published experimental systemic concentrations are made for molecules ranging from small lipophilic substances, such as ibuprofen, to polypeptides, such as calcitonin, and proteins, such as insulin.
It seems plausible that low-grade inflammation and endothelial dysfunction progressing to micro- and macrovascular complications account for higher systemic concentrations of CHI3L1.
Systemic concentrations of ET-1 and pro-endothelin-1 (big ET-1) were assessed in EDTA plasma using commercially available sandwich ELISA kits (BiomedicaGruppe, Austria).
In addition, low systemic concentrations may also have the benefit of falling outside the mutant selection window, thus reducing the risk of systemic resistance development [36, 37].
Higher systemic concentrations of CHI3L1 have been independently associated with the presence of coronary artery disease, seeming a quantitative indicator of disease progression as well [22].
DEM-TACE is focused to obtain higher concentrations of the drug to the tumor with lower systemic concentrations than traditional cancer chemotherapy.
Local (subcutaneous and skin), systemic concentrations and organ distribution (liver and kidney) were evaluated serially following topical and oral application of the drug.
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