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Many organs contain components involved in the synthesis and actions of the RAS, which are largely independent of the RAS systemic components and not accessible to routine laboratory testing [14, 15].
But Wheeler, from a similarly Heideggerian position, claims that the way to address the "inter-context" frame problem, as he calls it, is with a dynamical system in which "the causal contribution of each systemic component partially determines, and is partially determined by, the causal contributions of large numbers of other systemic components" (Wheeler 2008, 341).
This is of relevance as it will help to understand the importance of systemic components compared to intrinsic muscle factors, such as disuse, in sepsis-induced muscle atrophy.
Systemic components of regulation include parathyroid hormone, 1,25-dihydroxyvitamin D3, and calcitonin: local regulators include numerous cytokines and growth factors.
It can be speculated that the cellular model, methodology, or even the bioinformatic input are not yet appropriate to elucidate complex systemic components of cell biology.
Because it affects a limited number of joints and has no known systemic components, OA is well suited to local gene therapy [ 78].
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This scale may also be useful in studies or clinical trials evaluating the systemic component of UC.
This scale may also be useful in studies or clinical trials evaluating the systemic component of CD.
The co-morbidities of migraine with aura and stroke, ischemic heart disease, and cervical arterial dissection [47 53] indicate a vascular or systemic component in migraine.
However, given the possibility that SPA-induced ARDS may have a systemic component (as suggested by mild hypotension in two of the SPA-injured animals), further delineation of the systemic effects of SPA-associated ARDS should occur first.
It is not clear if the systemic inflammatory response represents a spillover of mediators from the lung or is primarily a separate systemic component to the disease [54, 55].
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