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It has been assumed the effects of systemic CM represent cocaine actions in peripheral tissues.
Therefore, systemic CM effects are not good measurements of cocaine actions through its peripheral targets.
Accordingly, several investigations examined the effects of systemic CM with the presumption that the results represented cocaine interactions with peripheral cocaine targets at similar doses [10], [13].
Our data with DRG neurons raises interesting questions about how systemic CM produces its effects which was hypothesized to result primarily from CM inhibition of peripheral Na+ channels [7].
It has been observed that the toxic effects of systemic CM, measured in vivo by median lethal doses (LD50), are similar to that of cocaine [11], [12], leading to the presumption that the potencies of CM and cocaine for peripheral targets might be similar.
Thereafter, two further perfusion measurements with different perfusion levels and systemic CM administration were performed, followed by a perfusion measurement with local CM administration.
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We also identified relevant comorbidities, including hypertension (ICD-9-CM 401.X-405.X), diabetes mellitus (ICD-9-CM 250.X), hyperlipidemia (ICD-9-CM 272.X), systemic lupus erythematous (ICD-9-CM 710.0), COPD (ICD-9-CM 491.X), rheumatoid arthritis (ICD-9-CM 714.0), and cancer (ICD-9-CM 140.X-208.X).
Patients were classified according to WHO classification [1], in CM, indolent systemic mastocytosis (ISM), smouldering systemic matocytosis (SSM), aggressive systemic mastocytosis (ASM) or systemic mastocytosis with an associated haematological clonal non-mast cell lineage disease (SM-AHNMD).
In addition to CM patients, systemic endothelial activation has been shown to occur in adults with uncomplicated and non-CM severe malaria [19], [27]; however, few studies have characterized the extent and significance of this process in pediatric SMA.
Furthermore, approximately 70% of patients with a wound infection had purulent discharge, erythema, edema, and an induration of ≥75 cm with systemic sign, such as fever ≥38 °C.
According to our findings, a scoring system based on four criteria (response to systemic therapy, ≤3 CLM, ≤3 cm lesion size, and low CEA level) may facilitate selection of patients for RFA treatment for whom best 5-year survival outcomes could be obtained.
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