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Given the systemic burden Bush left for his successor, that judgment seems to me to be less about fair play than about short memories.
Therefore, periodontal disease could contribute to increased local and systemic burden of ROS in expectant mothers.
A more accurate method of measuring the systemic burden of VCs could be developed to optimize risk stratification in high-risk dialysis patients [ 6].
Notably, infected Il22ra1−/− mice showed a high systemic burden of C. rodentium, accompanied by elevated serum titers of Citrobacter-specific IgG.
C-reactive protein (CRP) reflects the total systemic burden of inflammation in several disorders and has been shown to up regulate the production of proinflammatory cytokines [ 7].
This indicates that increased systemic burden of proinflammatory cytokines can be reduced by periodontal therapy, thus improving the patient's overall systemic condition.
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Because inflammation plays a major role in the atherosclerotic process [ 17], interest has focused on the impact of the systemic inflammatory burden and chronic activation of the immune system [ 18] present in RA [ 19, 20].
Regarding the relation between systemic inflammatory burden and diabetes, one study (22) reported the effect of periodontal treatment on hs-CRP blood levels in diabetic patients.
In this conceptualization, PE becomes more likely when the level of systemic inflammatory burden inherent in pregnancy itself exceeds the maternal capacity to compensate for this additional stress.
Nutrients with antioxidant properties, including vitamin E and selenium, are proposed to reduce systemic oxidative burden and thus to mitigate the negative health effects of reactive oxidant species.
If this is the case, then it is possible to hypothesize that conditions, such as infectious disease, that increase systemic inflammatory burden should also increase the risk of PE.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com