"If the code is tamper-resistant to protect against a hostile computer intruder or virus, and detects a systemic anomaly, then an accidental launch is a real possibility," says Nolan, now a principal with the Phoenix Consulting Group of Huntsville, Ala., a corporate intelligence agency.
Systemic anomalies may include facial dysmorphisms, dental anomalies, and redundant preumbilical skin.
Peters Plus Syndrome (PPS) [ 8] comprises anterior chamber defects along with other systemic anomalies.
However, KFS is usually associated with other multiple systemic anomalies such as scoliosis, visceral defects, deafness, and thoracic anomalies [ 21].
Deletion and splicing mutations have been reported in patients with Peter Plus Syndrome (PPS, #261540, Peters Anomalyy with variable systemic anomalies) [ 5, 22].
In fact, intragenic mutations and/or deletions in PITX2 and FOXC1 have been reported in ARS syndrome with or without systemic anomalies.
Clinically, a pediatric ophthalmologist confirmed the Peters Anomaly diagnosis of the patient, who was then referred to a pediatrician for an examination of associated systemic anomalies.
Based on in silico analysis and control data, the authors classified two missense and one nonsense (p.R286X) variants as pathogenic mutations; no inheritance pattern analysis was performed, and no additional systemic anomalies were documented for any of these cases (Lubbe et al. 2011).
Nonetheless, the patient should fit within certain criteria such as the primary congenital glaucoma with no other ocular or systemic anomalies, first diagnosed at least one month after birth but before on year of age, and the corneal diameters need to be less than 14 mm.
Depending on gestational age, thoracic and abdominal systemic vessel anomalies can also be detected [13].
Typically the onset is up to 3 years of age and the cornea may be affected in isolation or the sensory deficit may exist as a component of a congenital syndrome, or it may be associated with systemic somatic anomalies.
