Solid oral dosage formulations must be designed to produce predictable and consistent systemic drug exposure in the human body.
He castigates the MoD for its "corporate" and "systemic" failure to provide clear and consistent guidelines on how to treat prisoners or detainees.
To apply this curriculum design in practice, there needs to be a change – systemic, consistent, and from top to bottom.
CONCLUSIONS: The treatment effect of rivaroxaban compared with warfarin for the prevention of stroke and systemic embolism is consistent regardless of cTTR.
In a mouse model of asthma, initial immunization with ovalbumin in adjuvant followed by repeated daily exposure to aerosolized ovalbumin resulted in CD4+ T cell-dependent pulmonary eosinophilic inflammation and systemic IgE production, consistent with a Th2 immune response [ 79].
The marked elevation of both IFN-γ and IL-2 mRNA at the primary site of pathology, in contrast to the modest elevation of these lymphokines at a regional and systemic level, is consistent with the pre-eminently local character of AIA.
Antivenom is generally given for adults suffering severe local pain or symptoms of systemic envenomation consistent with latrodectism, which include pain and swelling spreading proximally from site, distressing local or systemic pain refractory to simple analgesia, chest pain, abdominal pain, or excessive sweating (diaphoresis).
Therefore, the combined data suggest that CY-injection in tumor-bearing mice results in systemic immune activation, consistent with the concept of immunogenic cell death [7], [18] and consistent with previously reported data [17], [29].
Thus, final classifications of studies are: (i) normal, (ii) abnormal and consistent with median mononeuropathy (mild or moderate/severe), and (iii) abnormal and consistent with systemic neuropathy.
These results indicate that the effect of erlotinib on improving the diabetes-induced nerve deficits in both myelinated and unmyelinated nerve fibers were not related to correction of the systemic hyperglycemia, consistent with our previous observation in diabetic C57Bl/6 mice [ 21]. *, p < 0.05 vs. Veh or Veh + Veh; #, p < 0.05 vs. Veh + Erlotinib (Erl).
