Sentence examples for systemic alterations from inspiring English sources

FRD induces multiple metabolic and endocrine systemic alterations which also alter PVAT and the vascular relaxant properties of this tissue.

Systemic alterations in the peripheral immune system of autoimmune disease patients have proved challenging to identify, particularly in organ-specific autoimmune diseases such as type 1 diabetes, in which onset of the first disease symptoms, namely autoantibodies, can precede clinical diagnosis by many years.

While main endpoints of miRNA changes in C. elegans included life span and metabolic modifications, studies in mammalian systems have focused on specific tissues and systemic alterations.

Our results suggest that the bone phenotype in dtd mice is a primary bone defect, which is not due to defects in osteoblast mineralization, osteoclast differentiation or systemic alterations, but to increased degradation of the altered organic bone matrix.

Along with these systemic alterations, ZDFs also demonstrate cardiac changes such as altered myocyte contraction and Ca2+ signaling at 9 to 13 weeks of age [ 23], mild diastolic dysfunction and increased collagen content at 45 weeks of age [ 24], as well as increased cardiac levels of triacylglycerol at 6 and 7 weeks of age [ 25, 26].

Our results support the hypothesis that localized laminar inflammation may be linked to systemic alterations in immune regulation, particularly in the gastrointestinal system.

Because the effects of TGF-β on osteoblast and osteoclast function are dynamic, dose-dependent, and specific for each cell type and stage of differentiation [4], [12] [14], prior studies do not indicate how the cell types present in mature bone will respond to a systemic alteration in TGF-β signaling.

Our results do not suggest a systemic alteration of the CCR3/CCL11 receptor/ligand complex in patients with neovascular AMD.

Malnutrition is a systemic alteration, potentially reversible, caused by imbalance between the nutrient intake and energy requirements [ 1].

The observation that Mao-B activities in brain and platelets correlate positively with ageing [ 107] has led researchers to suggest a systemic alteration of this potential neurological biomarker.

Nevertheless, perturbed expression of numerous PPAR target genes controlling fatty acid oxidization and transport, cholesterol metabolism, adipocyte differentiation, and gluconeogenesis suggested a systemic alteration of lipid homeostasis.