The Southwest Oncology Group-Intergroup Trial S0220 was designed to incorporate an active systemic agent, docetaxel, as consolidation therapy.
Initial deescalation studies for human papilloma virus (HPV -positive driven oropHPV -positiveamous cell carcinomas (HPV+ OPSCC) alteredrivenatioropharyngealsquamouse systemicellent used.
It is a multi kinase inhibitor, which can prolong the survival rate up to 20% and the only systemic agent approved for treating advanced, unresectable HCC on the basis of two phase III clinical trials.
Clonazepam as a topical and systemic agent has been evaluated with mixed outcomes [54, 55] but the significant side effect of drowsiness and the potential for addiction need to be taken into account.
PURPOSE: To investigate the hypothesis that a systemic agent designed to inhibit dihydropyrimidine dehydrogenase (DPD), the first enzyme in the fluoropyrimidine degradative pathway, could improve the effective amount of 5-fluorouracil (5-FU) delivered to a tumor resulting in enhanced response.
In addition, our results suggested a new therapeutic strategy whereby HPV+ tumor cell homing and invasion may be prevented by an approved systemic agent, Cidofovir.
It has an extensive safety history in humans, a large cloning capacity for insertion of therapeutic transgene payloads, is active as a systemic agent, lacks any known genotoxic activity and expresses a sophisticated array of immune modulating genes that can be exploited for therapeutic benefit [1].
No topical or systemic agent was used prophylactically post-operatively.
All received a systemic agent during radiation (83% chemotherapy, 17% biological agents).
BC-3781 is a novel semisynthetic systemic agent belonging to the pleuromutilin class of antibiotics.
The administration of a systemic agent could continue to promote bone repair for months after the index surgical procedure.
