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For systemic administration, novel delivery systems are required to confer "drug-like" pharmacokinetic and pharmacodynamic properties.
Two cases of drug delivery are investigated: systemic administration & polymer-based controlled release.
Compared with systemic administration, polymeric controlled release gives higher drug concentration with reduced systemic toxicity.
In diabetic vascular complications, systemic administration of statins is common.
For this application, systemic administration of nanodrugs is possible.
Yet systemic administration of IL-12 is toxic.
Also, dNPA displays anti-opioid activity after systemic administration.
Systemic administration of 3-nitropropionic acid (10 mg/kg i.p).
Goemans, N. M. et al. Systemic administration of PRO051 in Duchenne's muscular dystrophy.
Systemic administration of FBP promotes the accumulation of extracellular adenosine by an unknown mechanism15,20.
Peelaerts, W. et al. alpha-Synuclein strains cause distinct synucleinopathies after local and systemic administration.
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