Since many patients with isolated PC from CRC harbour undetected systemic disease and will eventually recur, the addition of potent systemic therapy to a locoregional approach such as CRS with HIPEC is warranted.
To establish if otorrhea associated to tympanostomy tubes in infants suffering from recurrent acute otitis media is similar to acute otitis media, and if topical treatment alone is sufficient or if addition of systemic antibiotics is required.
This effect seemed to be largely overcome by the addition of systemic therapy.
Only few attempts of boosting the immune response to vaccines by the addition of systemic doses of cytokines were made, mostly focused on immunological rather than clinical parameters (Lee et al, 2001; Maio et al, 2002).
These findings led us to propose that the addition of systemic NO to adequately volume resuscitated patients with septic shock results in an improvement of microcirculatory perfusion.
The addition of systemic adjuvant therapies, such as chemotherapy or hormonal treatment has been shown to increase the chance of long-term survival but also to increase side effects and costs.
An unblinded study using a porcine model of nifedipine-induced cardiogenic shock showed no differences in mortality or hemodynamic parameters (cardiac output, blood pressure, and systemic vascular resistance), following addition of phenylephrine to high-dose insulin (10 units/kg/h).
Addition of systemic nNOS blockade was associated with a reduction of both left (40 ± 2 vs 49 ± 2 ms at baseline; P =.001, Tukey-Kramer) and right (41 ± 2 vs 49 ± 2 ms at baseline; P =.03, Tukey-Kramer) vERP.
In contrast to patients with endocrine-sensitive or HER2-positive BC-BM, the addition of systemic therapy following WBRT has yet to yield improvements in survival for patients with TNBC-BM [ 3].
With this notion, it becomes increasingly important to understand how metastatic transformation can develop with the current treatments aimed at locoregional control, particularly since most early breast cancer patients with favourable phenotypic features will undergo lumpectomy with adjuvant radiation, often without the addition of systemic therapy.
